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KMID : 0390219990100020190
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Journal of Clinical Otolaryngology, Head and Neck Surgery
1999 Volume.10 No. 2 p.190 ~ p.194
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Existence of iNOS in the Human Cholesteatoma
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유인선/In Seon Yoo
추무진/신시옥/최영석/염창섭/Moo Jin Choo/See Ok Shin/Young Seok Choi/Chang Seop Yum
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Abstract
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Background and Objectives : Bone resorption and hyperkeratosis are the most
characteristic findings of chromic otitis media with cholesteatoma. Overexpression of
IL-1 in cholesteatoma was reported having a significant role in tile pathogenesis of
cholesteatoma. Also, overproduction of nitric oxide (NO) stimulated the production of the
cyclooxygenase and PGE2. Therefore, NO and inducible nitric oxide
synthase (iNOS) may be suggested having a role of the pathogenesis of cholesteatoma.
This study was designed to identity the existence of iNOS in human Cholesteatoma.
Materials and Methods : Ten fresh human cholesteatoma tissues and one postauricular
skin were used. Dot and Western blot analysis were used for detection of iNOS.
Results : Dot bolt showed different degrees of response. The bands ol iNOS about 137
kDa area existed in the Western blot analysis.
Conclusion : These findings suggest that iNOS may present in human cholesteatoma
and NO may have play a role in pathogenesis of chronic otitis media with cholesteatoma.
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